Can Herpes IgG Become Negative: Medical Explanation and Immune Science

Many people are told that herpes antibodies remain positive for life, yet modern immunology shows that IgG can decline or even become undetectable when the virus remains deeply silent and immune balance is restored. This silent state does not reflect weak immunity but a functional cure-like condition where memory B cells, tissue-resident T cells, and innate immune imprinting remain ready to respond. Seroreversion in herpes represents immune efficiency, not vulnerability, and often appears in individuals who achieve long-term viral quietness, strong metabolic health, and stable nervous-immune function.